Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Norbert Stefan"
Filter
Filter
Article type
Keywords
Publication year
Authors
Review Article
Obesity and Metabolism
Metabolically Healthy and Unhealthy Normal Weight and Obesity
Norbert Stefan
Endocrinol Metab. 2020;35(3):487-493.   Published online August 20, 2020
DOI: https://doi.org/10.3803/EnM.2020.301
  • 9,148 View
  • 439 Download
  • 31 Web of Science
  • 32 Crossref
AbstractAbstract PDFPubReader   ePub   
Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality. However, also very low fat mass associates with such an increased risk. Whether impaired metabolic health, characterized by hypertension, dyslipidemia, hyperglycemia, insulin resistance, and subclinical inflammation, may explain part of the elevated risk of cardiometabolic diseases that is found in many subjects with very low fat mass, as it does in many obese subjects, is unknown. An important pathomechanism of impaired metabolic health is disproportionate fat distribution. In this article the risk of cardiometabolic diseases and mortality in subjects with metabolically healthy and unhealthy normal weight and obesity is summarized. Furthermore, the change of metabolic health during a longer period of follow-up and its impact on cardiometabolic diseases is being discussed. Finally, the implementation of the concept of metabolic health in daily clinical practice is being highlighted.

Citations

Citations to this article as recorded by  
  • Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight
    Rachel Agius, Nikolai P. Pace, Stephen Fava
    Diabetes/Metabolism Research and Reviews.2024;[Epub]     CrossRef
  • Comparing verum and sham acupoint catgut embedding for adults with obesity: A systematic review and meta-analysis of randomized clinical trials
    Jin-huan Yue, Xiao-ling Li, Yu-ying Zhang, Guan-hu Yang, Jeffrey Zhong-xue Mah, Ang Li, Wei-wei Zhao, Yu-lin Wang, Qin-hong Zhang, Jia-qi Huang
    Medicine.2024; 103(4): e36653.     CrossRef
  • Association between Weight Change and Incidence of Dyslipidemia in Young Adults: A Retrospective Cohort Study of Korean Male Soldiers
    Joon-Young Yoon, Won Ju Park, Hee Kyung Kim, Ho-Cheol Kang, Cheol-Kyu Park, Wonsuk Choi
    Journal of Obesity & Metabolic Syndrome.2024; 33(1): 36.     CrossRef
  • Dietary intake of methyl donor nutrients in relation to metabolic health status, serum levels of brain-derived neurotrophic factor and adropin
    Donya Poursalehi, Keyhan Lotfi, Farnaz Shahdadian, Zahra Hajhashemy, Parisa Rouhani, Parvane Saneei
    Clinical Nutrition.2024; 43(6): 1353.     CrossRef
  • Metabolically Healthy Obesity: An Eye-opener
    Purushothaman Padmanabhan, Nagendram Dinakaran, Somnath Verma, S Keerthana
    Gastroenterology, Hepatology and Endoscopy Practice.2023; 3(1): 1.     CrossRef
  • Effect of metabolic health and obesity on all-cause death and CVD incidence in Korean adults: a retrospective cohort study
    Ye-Seul Kim, Sang-Jun Shin, Yonghwan Kim, Joungyoun Kim, Hee-Taik Kang
    Scientific Reports.2023;[Epub]     CrossRef
  • Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study
    Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(3): 620.     CrossRef
  • Metabolically unhealthy phenotype in adults with normal weight: Is cardiometabolic health worse off when compared to adults with obesity?
    Myong-Won Seo, Joon Young Kim
    Obesity Research & Clinical Practice.2023; 17(2): 116.     CrossRef
  • Association between metabolic obesity phenotypes and multiple myeloma hospitalization burden: A national retrospective study
    Yue Zhang, Xiude Fan, Chunhui Zhao, Zinuo Yuan, Yiping Cheng, Yafei Wu, Junming Han, Zhongshang Yuan, Yuanfei Zhao, Keke Lu
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Metabolically healthy obesity: Misleading phrase or healthy phenotype?
    Cem Tanriover, Sidar Copur, Abduzhappar Gaipov, Batu Ozlusen, Rustu E. Akcan, Masanari Kuwabara, Mads Hornum, Daniel H. Van Raalte, Mehmet Kanbay
    European Journal of Internal Medicine.2023; 111: 5.     CrossRef
  • Prevalence of combined metabolic health and weight status by various diagnosis criteria and association with cardiometabolic disease in Korean adults
    Myong-Won Seo, Jung-Min Lee, Hyun Chul Jung
    Obesity Research & Clinical Practice.2023; 17(2): 137.     CrossRef
  • Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification
    Åsa Johansson, Ole A. Andreassen, Søren Brunak, Paul W. Franks, Harald Hedman, Ruth J. F. Loos, Benjamin Meder, Erik Melén, Craig E. Wheelock, Bo Jacobsson
    Journal of Internal Medicine.2023; 294(4): 378.     CrossRef
  • Lipid droplet biogenesis and functions in health and disease
    Armella Zadoorian, Ximing Du, Hongyuan Yang
    Nature Reviews Endocrinology.2023; 19(8): 443.     CrossRef
  • Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity
    Dariusz Szukiewicz
    International Journal of Molecular Sciences.2023; 24(12): 9818.     CrossRef
  • Insulin Resistance Is the Main Characteristic of Metabolically Unhealthy Obesity (MUO) Associated with NASH in Patients Undergoing Bariatric Surgery
    Sophia M. Schmitz, Sebastian Storms, Alexander Koch, Christine Stier, Andreas Kroh, Karl P. Rheinwalt, Sandra Schipper, Karim Hamesch, Tom F. Ulmer, Ulf P. Neumann, Patrick H. Alizai
    Biomedicines.2023; 11(6): 1595.     CrossRef
  • Hyperleptinemia as a marker of various phenotypes of obesity and overweight in women with rheumatoid arthritis and systemic lupus erythematosus
    L. V. Kondrateva, Yu. N. Gorbunova, T. A. Panafidina, T. V. Popkova
    Rheumatology Science and Practice.2023; 61(3): 339.     CrossRef
  • Predictable Representation of Metabolic Synthesis Pathways of Vitamins and Short-Chain Fatty Acids in Obese Adults
    A. V. Shestopalov, L. A. Ganenko, I. M. Kolesnikova, T. V. Grigoryeva, I. Yu. Vasilyev, Yu. L. Naboka, N. I. Volkova, O. V. Borisenko, S. A. Roumiantsev
    Journal of Evolutionary Biochemistry and Physiology.2023; 59(5): 1510.     CrossRef
  • PREDICTION OF VITAMINS AND SHORT-CHAIN FATTY ACIDS SYNTHESIS PATHWAYS IN OBESE ADULTS
    A. V. Shestopalov, L. A. Ganenko, I. M. Kolesnikova, T. V. Grigoryeva, I. Yu. Vasilyev, Yu. L. Naboka, N. I. Volkova, O. V Borisenko, S. A. Roumiantsev
    Журнал эволюционной биохимии и физиологии.2023; 59(5): 389.     CrossRef
  • Metabolically unhealthy individuals, either with obesity or not, have a higher risk of critical coronavirus disease 2019 outcomes than metabolically healthy individuals without obesity
    Nam Hoon Kim, Kyeong Jin Kim, Jimi Choi, Sin Gon Kim
    Metabolism.2022; 128: 154894.     CrossRef
  • Associations between obesity, metabolic syndrome, and endometrial cancer risk in East Asian women
    Boyoung Park
    Journal of Gynecologic Oncology.2022;[Epub]     CrossRef
  • Insulin and cancer: a tangled web
    Brooks P. Leitner, Stephan Siebel, Ngozi D. Akingbesote, Xinyi Zhang, Rachel J. Perry
    Biochemical Journal.2022; 479(5): 583.     CrossRef
  • Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study
    Shao-Chi Chu, Po-Hsi Wang, Kuan-Ying Lu, Chia-Chun Ko, Yun-Hsuan She, Chin-Chan Lee, I-Wen Wu, Chiao-Yin Sun, Heng-Jung Hsu, Heng-Chih Pan
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Dissecting the clinical relevance of polygenic risk score for obesity—a cross-sectional, longitudinal analysis
    Eun Kyung Choe, Manu Shivakumar, Seung Mi Lee, Anurag Verma, Dokyoon Kim
    International Journal of Obesity.2022; 46(9): 1686.     CrossRef
  • Metabolic and Obesity Phenotype Trajectories in Taiwanese Medical Personnel
    Hsin-Yun Chang, Jer-Hao Chang, Yin-Fan Chang, Chih-Hsing Wu, Yi-Ching Yang
    International Journal of Environmental Research and Public Health.2022; 19(13): 8184.     CrossRef
  • Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
    Haneen S. Dwaib, Ibrahim AlZaim, Ghina Ajouz, Ali H. Eid, Ahmed El-Yazbi
    Molecular Pharmacology.2022; 102(1): 60.     CrossRef
  • Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity
    Rachel Agius, Nikolai Paul Pace, Stephen Fava
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Changes in BMI and physical activity from youth to adulthood distinguish normal-weight, metabolically obese adults from those who remain healthy
    A. Viitasalo, K. Pahkala, T. Lehtimäki, JSA. Viikari, TH. Tammelin, O. Raitakari, TO. Kilpeläinen
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Pathogenesis, Murine Models, and Clinical Implications of Metabolically Healthy Obesity
    Yun Kyung Cho, Yoo La Lee, Chang Hee Jung
    International Journal of Molecular Sciences.2022; 23(17): 9614.     CrossRef
  • Metabolically healthy obesity: it is time to consider its dynamic changes
    Yun Kyung Cho, Chang Hee Jung
    Cardiovascular Prevention and Pharmacotherapy.2022; 4(4): 123.     CrossRef
  • Obesity as a Risk Factor for Breast Cancer—The Role of miRNA
    Karolina Hanusek, Jakub Karczmarski, Anna Litwiniuk, Katarzyna Urbańska, Filip Ambrozkiewicz, Andrzej Kwiatkowski, Lidia Martyńska, Anita Domańska, Wojciech Bik, Agnieszka Paziewska
    International Journal of Molecular Sciences.2022; 23(24): 15683.     CrossRef
  • Propensity Score–Matching Sleeve Gastrectomy (SG) vs. Gastric Bypass (RYGB) in Patients ≥ 60 Years
    Omar Thaher, Stefanie Wolf, Martin Hukauf, Christine Stroh
    Obesity Surgery.2021; 31(6): 2682.     CrossRef
  • Associations between obesity, metabolic health, and the risk of breast cancer in East Asian women
    Boyoung Park, Soyeoun Kim, Hayoung Kim, Chihwan Cha, Min Sung Chung
    British Journal of Cancer.2021; 125(12): 1718.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism